CBX5 Antikörper (Chromobox Homolog 5) (AA 88-117)

Details for Product anti-CBX5 Antibody No. ABIN657701, Anbieter: Anmelden zum Anzeigen
Antigen
  • HP1
  • HP1A
  • id:ibd2026
  • wu:fc63e02
  • wu:fe47g12
  • wu:fi03h05
  • zgc:158601
  • CBX5
  • cbx5
  • MGC64354
  • 2610029O15Rik
  • C75991
  • Hp1a
  • Hp1alpha
  • chromobox 5
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • chromobox 5 S homeolog
  • CBX5
  • cbx5
  • Cbx5
  • cbx5.S
Epitop
AA 88-117, Center
21
20
15
15
13
12
12
8
8
7
7
7
5
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
210
115
48
17
16
10
8
5
5
5
4
4
2
1
Wirt
Kaninchen
176
46
24
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser CBX5 Antikörper ist unkonjugiert
10
8
7
5
5
5
2
2
2
2
2
2
2
2
2
2
2
Applikation
Western Blotting (WB)
199
116
93
38
32
27
26
20
14
7
7
4
3
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 AA from the Central region of human CBX5.
Klon RB33905
Isotyp Ig Fraction
Spezifität This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-1117 amino acids from the Central region of human CBX5.
Homologie Mouse (Murine)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Plasmids, Primers & others Plasmide, Primers & weitere CBX5 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung CBX5 (CBX5 Antibody Abstract)
Hintergrund This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms: Chromobox protein homolog 5,CBX5,HP1A
Molekulargewicht 22225 DA
Gen-ID 23468
NCBI Accession NP_001120793, NP_001120794, NP_036249
UniProt P45973
Applikations-hinweise WB = 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.28 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung CBX5 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Chromobox Homolog 5 (CBX5) (AA 88-117), (Center) antibody (ABIN657701) CBX5 Antibody (Center) (ABIN657701) western blot analysis in CEM cell line lysates (3...
Allgemeine Veröffentlichungen Nozawa, Nagao, Masuda, Iwasaki, Hirota, Nozaki, Kimura, Obuse: "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation." in: Nature cell biology, Vol. 12, Issue 7, pp. 719-27, 2010 (PubMed).

Emelyanov, Konev, Vershilova, Fyodorov: "Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo." in: The Journal of biological chemistry, Vol. 285, Issue 20, pp. 15027-37, 2010 (PubMed).

Kiyomitsu, Iwasaki, Obuse, Yanagida: "Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes." in: The Journal of cell biology, Vol. 188, Issue 6, pp. 791-807, 2010 (PubMed).

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