CCAR2 Antikörper
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- Target Alle CCAR2 Antikörper anzeigen
- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CCAR2 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF), Immunohistochemistry (IHC)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human CCAR2 (NP_066997.3).
- Isotyp
- IgG
- Top Product
- Discover our top product CCAR2 Primärantikörper
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- Applikationshinweise
- IHC 1:50-1:200 IF 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
- Andere Bezeichnung
- CCAR2 (CCAR2 Produkte)
- Synonyme
- DBC-1 antikoerper, DBC1 antikoerper, KIAA1967 antikoerper, NET35 antikoerper, p30 DBC antikoerper, p30DBC antikoerper, 2610301G19Rik antikoerper, mKIAA1967 antikoerper, RGD1309922 antikoerper, Kiaa1967 antikoerper, cell cycle and apoptosis regulator 2 antikoerper, cell cycle activator and apoptosis regulator 2 antikoerper, CCAR2 antikoerper, Ccar2 antikoerper
- Hintergrund
- Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation, stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
- Molekulargewicht
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Observed_MW: 100kDa
Calculated_MW: 102kDa/103kDa
- Gen-ID
- 57805
- UniProt
- Q8N163
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