AF4 Antikörper
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- Target Alle AF4 (AFF1) Produkte
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser AF4 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human AFF1 (NP_001160165.1).
- Isotyp
- IgG
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- Applikationshinweise
- IF 1:50-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
- Andere Bezeichnung
- AFF1 (AFF1 Produkte)
- Synonyme
- AF4 antikoerper, MLLT2 antikoerper, PBM1 antikoerper, 9630032B01Rik antikoerper, AW319193 antikoerper, Af4 antikoerper, Mllt2h antikoerper, Rob antikoerper, Mllt2 antikoerper, AF4/FMR2 family member 1 antikoerper, AF4/FMR2 family, member 1 antikoerper, AFF1 antikoerper, Aff1 antikoerper
- Hintergrund
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
- Molekulargewicht
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Observed_MW: Refer to figures
Calculated_MW: 131kDa/132kDa
- Gen-ID
- 4299
- UniProt
- P51825
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