Tryptase alpha/beta 1 (TPSAB1) Antikörper

Details zu Produkt Nr. ABIN6569054
Target
Reaktivität
Human, Maus
45
26
12
8
3
2
2
2
2
1
Wirt
Kaninchen
67
21
1
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
18
5
4
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
77
46
31
12
11
10
10
8
6
2
2
2
1
Optionen
Immunogen Recombinant protein of human TPSAB1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung TPSAB1 (TPSAB1 Antibody Abstract)
Hintergrund

Synonyms: alpha II,Lung tryptase,Mast cell alpha II tryptase,Mast cell beta I tryptase,Mast cell protease 7,Mast cell protease II,MCP 7,Pituitary tryptase,Skin tryptase,TPS 1,TPS1,TPS2,TPSAB1,TPSAB1 protein,TPSB1,Tryptase 1,Tryptase alpha 1,tryptase alpha I included,Tryptase alpha II,tryptase alpha II included,tryptase alpha included,tryptase alpha/beta 1,Tryptase beta 1,tryptase beta I included,Tryptase I,tryptase I included,Tryptase III,Tryptase skin

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Molekulargewicht

Observed_MW: 33kDa

Calculated_MW: 29kDa/30kDa

Gen-ID 7177
UniProt Q15661
Applikations-hinweise WB 1:500 - 1:2000 IF 1:20 - 1:50
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Tryptase alpha/beta 1 (TPSAB1) antibody (ABIN6569054) Immunofluorescence analysis of HeLa cells using TPSAB1 antibody.
Image no. 2 for anti-Tryptase alpha/beta 1 (TPSAB1) antibody (ABIN6569054) Western blot analysis of extracts of various cell lines, using TPSAB1 antibody.