PTPN2 Antikörper (Protein tyrosine Phosphatase, Non-Receptor Type 2)

Details for Product anti-PTPN2 Antibody No. ABIN6568912
Target
Reaktivität
Human, Ratte
47
24
21
6
5
5
5
5
4
2
2
1
1
Wirt
Kaninchen
47
3
Klonalität
Polyklonal
Konjugat
Dieser PTPN2 Antikörper ist unkonjugiert
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
44
26
22
6
5
3
2
1
1
1
Optionen
Immunogen Recombinant protein of human PTPN2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PTPN2 (PTPN2 Antibody Abstract)
Hintergrund

Synonyms: Protein tyrosine phosphatase non receptor type 2,PTN2,PTN2,PTPN 2,Ptpn2,PTPT,T cell protein tyrosine phosphatase,T-cell protein-tyrosine phosphatase,TC PTP,TCELLPTP,TCPTP,Tyrosine protein phosphatase non receptor type 2,Tyrosine-protein phosphatase non-receptor type 2

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

Molekulargewicht

Observed_MW: 45kDa

Calculated_MW: 40kDa/45kDa/48kDa

Gen-ID 5771
UniProt P17706
Pathways EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) antibody (ABIN6568912) Immunohistochemistry of paraffin-embedded rat heart using PTPN2 antibody.
Image no. 2 for anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) antibody (ABIN6568912) Immunofluorescence analysis of MCF-7 cells using PTPN2 antibody.
Image no. 3 for anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) antibody (ABIN6568912) Western blot analysis of extracts of various cell lines, using PTPN2 antibody.