Synonyms: Beta1i,Large multifunctional peptidase 2,Large multifunctional protease 2,LMP 2,LMP2,Low molecular mass protein 2,Macropain chain 7,MGC70470,Multicatalytic endopeptidase complex chain 7,OTTHUMP00000062982,Proteasome (prosome macropain) subunit beta type 9,proteasome (prosome,macropain) subunit,beta type,9 (large multifunctional peptidase 2),Proteasome beta 9 subunit,Proteasome catalytic subunit 1i,Proteasome chain 7,Proteasome related gene 2,Proteasome subunit beta 6i,Proteasome subunit beta type 9,Proteasome subunit beta type-9,Proteasome subunit beta-1i,PSB9,PSMB 9,PSMB6i,PSMB9,Really interesting new gene 12 protein,RING 12,RING12,RING12 protein
Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.