Synonyms: HSMRK222,K222,K222TA2,Metalloproteinase inhibitor 3,MIG 5 protein,MIG5 protein,Protein MIG 5,Protein MIG-5,SFD,Sorsby fundus dystrophy pseudoinflammatory,TIMP 3,TIMP metallopeptidase inhibitor 3,TIMP-3,TIMP3,TIMP3,Tissue Inhibitor of Metalloproteinase 3,Tissue inhibitor of metalloproteinases 3,Tissue inhibitor of metalloproteinases3
Background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.