CTCF Antikörper (CCCTC-Binding Factor (Zinc Finger Protein))

Details for Product anti-CTCF Antibody No. ABIN6567117
Target
Reaktivität
Human, Affe, Maus, Ratte
60
42
35
9
7
7
6
6
5
4
4
2
1
1
1
1
Wirt
Kaninchen
49
9
6
1
1
Klonalität
Polyklonal
Konjugat
Dieser CTCF Antikörper ist unkonjugiert
2
2
2
2
2
2
2
Applikation
Western Blotting (WB)
52
17
17
11
10
9
7
5
4
2
2
2
1
1
Optionen
Immunogen Recombinant protein of human CTCF
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung CTCF (CTCF Antibody Abstract)
Hintergrund

Synonyms: 11 zinc finger protein,11 zinc finger transcriptional repressor,11-zinc finger protein,CCCTC binding factor (zinc finger protein),CCCTC binding factor,CCCTC-binding factor,Ctcf,CTCF,CTCFL paralog,MRD21,Transcriptional repressor CTCF

Background: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 135kDa

Calculated_MW: 45kDa/82kDa

Gen-ID 10664
UniProt P49711
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) antibody (ABIN6567117) Western blot analysis of extracts of various cell lines, using CTCF antibody.