CRH Antikörper (C-Term)

Produktnummer ABIN655191

Produktdetails anti-CRH Antikörper

Target: CRH (Corticotropin Releasing Hormone (CRH))

Bindungsspezifität: AA 129-156, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CRH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-156 amino acids from the C-terminal region of human CRH.

Klon: RB23963

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu CRH

Target: CRH (Corticotropin Releasing Hormone (CRH))

Andere Bezeichnung: CRH (CRH Produkte)

Synonyme: CRF antikoerper, Gm1347 antikoerper, crf antikoerper, crh antikoerper, zgc:101864 antikoerper, CRH antikoerper, corticoliberin antikoerper, crhb antikoerper, crh.1-a antikoerper, crha antikoerper, corticotropin releasing hormone antikoerper, corticotropin releasing hormone b antikoerper, corticotropin releasing hormone S homeolog antikoerper, corticotropin releasing hormone L homeolog antikoerper, Crh antikoerper, CRH antikoerper, crhb antikoerper, crh antikoerper, crh.S antikoerper, crh.L antikoerper

Hintergrund: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Molekulargewicht: 21422

Gen-ID: 1392

NCBI Accession: NP_000747

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour