RAN Antikörper (RAN, Member RAS Oncogene Family) (AA 112-140)

Details for Product anti-RAN Antibody No. ABIN652226, Anbieter: Anmelden zum Anzeigen
Antigen
  • ARA24
  • Gsp1
  • TC4
  • ran
  • ara24
  • gsp1
  • ran-1
  • tc4
  • RAN
  • RANP1
  • M2
  • Ran
  • Ran/M2
  • Rasl2-9-ps
  • AAF30287
  • CG1404
  • Dmel\CG1404
  • dran
  • l(1)G0075
  • ran10A
  • fc16b04
  • wu:fc16b04
  • RAN, member RAS oncogene family
  • RAN, member RAS oncogene family S homeolog
  • RAS-like, family 2, locus 9
  • CG1404 gene product from transcript CG1404-RC
  • RAN
  • Ran
  • ran.S
  • ran
  • Rasl2-9
Epitop
AA 112-140, Center
21
20
10
9
8
7
5
5
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
160
116
89
16
14
13
11
9
7
4
3
3
3
3
2
1
1
Wirt
Kaninchen
117
33
11
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser RAN Antikörper ist unkonjugiert
6
6
6
4
4
4
2
2
2
2
2
2
2
2
2
2
2
Applikation
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
126
72
50
26
25
24
19
15
11
3
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This RAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 AA from the Central region of human RAN.
Klon RB20230
Isotyp Ig Fraction
Spezifität This RAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human RAN.
Homologie Cow (Bovine),Chicken,Fruit Fly (Drosophila melanogaster),Monkey,Rat (Rattus),Xenopus laevis,Zebrafish
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung RAN (RAN Antibody Abstract)
Hintergrund RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Synonyms: RAN,GTP-binding nuclear protein Ran,ARA24
Molekulargewicht 24423 DA
Gen-ID 5901
NCBI Accession NP_006316
UniProt P62826
Forschungsgebiet Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Chromatin, Cell Structure
Pathways Regulatorische RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
Applikationshinweise WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-RAN, Member RAS Oncogene Family (RAN) (AA 112-140), (Center) antibody (ABIN652226) RAN Antibody (Center) (ABIN652226) western blot analysis in mouse NIH-3T3 cell line l...
Immunohistochemistry (IHC) image for anti-RAN, Member RAS Oncogene Family (RAN) (AA 112-140), (Center) antibody (ABIN652226) RAN antibody (Center) (ABIN652226) immunohistochemistry analysis in formalin fixed an...
Allgemeine Veröffentlichungen Mishra, Chakraborty, Arnaoutov, Fontoura, Dasso: "The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores." in: Nature cell biology, Vol. 12, Issue 2, pp. 164-9, 2010 (PubMed).

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