Nerve Growth Factor 2.5S Antikörper

Produktnummer ABIN641051

Produktdetails

Target: Nerve Growth Factor 2.5S

Reaktivität: Maus

Wirt: Schaf

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB), Functional Studies (Func)

Spezifität: DS-PB-01450 reacts with the beta subunit of mouse NGF in both the 2.5S and 7S forms. It does not react with mice serum proteins, renin or epidermal growth factor. NGF is a multimeric protein that promotes nerve cell growth and may protect some types of nerve cells from damage, including nerve cells in the cholinergic system.

Produktmerkmale: Sheep Anti-Nerve Growth Factor 2.5S

Aufreinigung: Purified

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Supplied as 1.0mg of purified antibody. Reconstitute with 1.0ml distilled water. Please avoid freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: Nerve Growth Factor 2.5S

Hintergrund: Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin- 4 (NT-4) (also designated NT-5). These various neurotrophins stimulate the in vitro survival of distinct, but partially overlapping, populations of neurons. The cell surface receptors through which neurotrophins mediate their activity have been identified. For instance, the Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds both BDNF and NT-4 equally well, and binds NT-3 to a lesser extent, while the Trk C receptor only binds NT-3.