COL25A1 Antikörper (AA 155-169)

Produktnummer ABIN636294

Produktdetails anti-COL25A1 Antikörper

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Bindungsspezifität: AA 155-169

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL25A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity chromatography purified

Immunogen: CLACP antibody was raised in rabbit using AA 155-169 [KGEQGDQGPRMVFPK] of the NC2-2 region of human and mouse CLAC-P as the immunogen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500
Optimal conditions should be determined by the investigator.

Kommentare:

This antibody producess bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: Affinity purified IgG supplied in PBS with 0.02 % NaN3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Details zu COL25A1

Target: COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))

Andere Bezeichnung: CLACP (COL25A1 Produkte)

Synonyme: COL25A1 antikoerper, AMY antikoerper, CLAC antikoerper, CLAC-P antikoerper, CLACP antikoerper, 2700062B08Rik antikoerper, collagen type XXV alpha 1 chain antikoerper, collagen, type XXV, alpha 1 antikoerper, COL25A1 antikoerper, col25a1 antikoerper, Col25a1 antikoerper

Hintergrund: The 9D2 antigen isolated from senile plaque amyloid was identified as collagen-like Alzheimer amyloid plaque component (CLAC), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bind to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.