NSMCE2 Antikörper

Produktnummer ABIN631769

Produktdetails anti-NSMCE2 Antikörper

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSMCE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purified

Immunogen: NSMCE2 antibody was raised using a synthetic peptide corresponding to a region with amino acids KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE

Anwendungsinformationen

Applikationshinweise: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

NSMCE2 Blocking Peptide, catalog no. 33R-4372, is also available for use as a blocking control in assays to test for specificity of this NSMCE2 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of NSMCE2 antibody in PBS

Konzentration: Lot specific

Buffer: PBS

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Details zu NSMCE2

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Andere Bezeichnung: NSMCE2 (NSMCE2 Produkte)

Synonyme: 1110014D18Rik antikoerper, AI661537 antikoerper, RGD1305156 antikoerper, C8orf36 antikoerper, MMS21 antikoerper, NSE2 antikoerper, ZMIZ7 antikoerper, Non-SMC element 2 antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog antikoerper, Smc5-6 complex non-SMC subunit 2 antikoerper, Nsmce2 antikoerper, NSMCE2 antikoerper, nsmce2.L antikoerper, nse2 antikoerper

Hintergrund: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Molekulargewicht: 28 kDa (MW of target protein)