CDT2/RAMP Antikörper (Center)
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- Target Alle CDT2/RAMP (DTL) Antikörper anzeigen
- CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
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Bindungsspezifität
- AA 229-256, Center
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CDT2/RAMP Antikörper ist unkonjugiert
- Applikation
- Bitte anfragen
- Verwendungszweck
- Rabbit Anti-DTL (Center) Antibody
- Immunogen
- This DTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-256 amino acids from the Central region of human DTL.
- Top Product
- Discover our top product DTL Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
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- Target
- CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
- Andere Bezeichnung
- DTL (DTL Produkte)
- Synonyme
- CDT2 antikoerper, DCAF2 antikoerper, L2DTL antikoerper, RAMP antikoerper, 2810047L02Rik antikoerper, 5730564G15Rik antikoerper, Ramp antikoerper, RGD1310439 antikoerper, cdt2 antikoerper, cdt2-a antikoerper, dcaf2 antikoerper, l2dtl antikoerper, ramp antikoerper, cb151 antikoerper, chunp6871 antikoerper, wu:fb54b02 antikoerper, denticleless E3 ubiquitin protein ligase homolog antikoerper, denticleless E3 ubiquitin protein ligase antikoerper, denticleless E3 ubiquitin protein ligase homolog S homeolog antikoerper, denticleless E3 ubiquitin protein ligase homolog (Drosophila) antikoerper, DTL antikoerper, Dtl antikoerper, dtl.S antikoerper, dtl antikoerper
- Hintergrund
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Target Description: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Gene Symbol: DTL
- Gen-ID
- 51514
- UniProt
- Q9NZJ0
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