SIRT2 Antikörper

Produktnummer ABIN6291363

Produktdetails anti-SIRT2 Antikörper

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human SIRT2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Kommentare:

Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex, Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver, Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues, Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level), Widely expressed, Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung, Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Andere Bezeichnung: SIRT2 (SIRT2 Produkte)

Synonyme: CG5085 antikoerper, D.mel2 antikoerper, Dmel\\CG5085 antikoerper, SIRT2 antikoerper, dSIRT2 antikoerper, sir2 antikoerper, Sirt2 antikoerper, BmSirt2 antikoerper, AtSRT2 antikoerper, SIRTUIN 2 antikoerper, T2K12.8 antikoerper, sirtuin 2 antikoerper, SIR2 antikoerper, SIR2L antikoerper, SIR2L2 antikoerper, 5730427M03Rik antikoerper, Sir2l antikoerper, wu:fb57d05 antikoerper, zgc:55966 antikoerper, zgc:77003 antikoerper, Sirtuin 2 antikoerper, sirtuin 2 antikoerper, sirtuin 2 S homeolog antikoerper, NAD-dependent deacetylase sirtuin 2 homolog antikoerper, sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) antikoerper, Sirt2 antikoerper, SIRT2 antikoerper, sirt2.S antikoerper, SRT2 antikoerper, sirt2 antikoerper

Hintergrund: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Molekulargewicht: 43.182 kDa

Gen-ID: 22933

UniProt: Q8IXJ6