Reticulon 3 Antikörper

Produktnummer ABIN6291193

Produktdetails anti-Reticulon 3 Antikörper

Target: Reticulon 3 (RTN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Reticulon 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human RTN3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Kommentare:

Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level), Three times more abundant in macula than in peripheral retina, Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle, Isoform 2 is only found in melanoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu Reticulon 3

Target: Reticulon 3 (RTN3)

Andere Bezeichnung: RTN3 (RTN3 Produkte)

Synonyme: ASYIP antikoerper, HAP antikoerper, NSPL2 antikoerper, NSPLII antikoerper, RTN3-A1 antikoerper, MGC56439 antikoerper, zgc:56439 antikoerper, zgc:77630 antikoerper, RTN3 antikoerper, hap antikoerper, asyip antikoerper, nspl2 antikoerper, xrtn3 antikoerper, nsplii antikoerper, rtn3-a1 antikoerper, RTN3w antikoerper, rtn3 antikoerper, XRTN3 antikoerper, rtn3-a antikoerper, rtn3-b antikoerper, reticulon 3 antikoerper, reticulon 3 L homeolog antikoerper, reticulon-3 antikoerper, reticulon 3 S homeolog antikoerper, RTN3 antikoerper, Rtn3 antikoerper, rtn3 antikoerper, rnt3 antikoerper, rtn3.L antikoerper, LOC107131155 antikoerper, rtn3.S antikoerper

Hintergrund: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

Molekulargewicht: 112.611 kDa

Gen-ID: 10313

UniProt: O95197