tau Antikörper (pSer396)

Produktnummer ABIN6288003

Produktdetails anti-tau Antikörper

Target: tau (tau Protein)

Bindungsspezifität: AA 650-730, pSer396

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser tau Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Tau is a protein encoded by the MAPT gene which is approximately 78,9 kDa. Tau is localised to the cytoplasm and cell membrane. It is involved in the apoptotic cleavage of cellular proteins, MAPK signalling pathway, CDK-mediated phosphorylation and removal of Cdc6 and development slit-robo signalling. It promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein. Tau is expressed in neurons. Mutations in the MAPT gene may result in Frontotemporal dementia. STJ90423 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Tau protein which only binds about S396 when S396 is phosphorylated.

Spezifität: Phospho-Tau (S396) Polyclonal Antibody detects endogenous levels of Tau protein only when phosphorylated at S396.

Produktmerkmale: Rabbit polyclonal to Phospho-Tau (S396).

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Tau around the phosphorylation site of S396.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
ELISA 1:20000

Kommentare:

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu tau

Target: tau (tau Protein)

Andere Bezeichnung: Tau (tau Produkte)

Synonyme: DDPAC antikoerper, FTDP-17 antikoerper, MAPTL antikoerper, MSTD antikoerper, MTBT1 antikoerper, MTBT2 antikoerper, PPND antikoerper, TAU antikoerper, tau antikoerper, PHF-tau antikoerper, microtubule associated protein tau antikoerper, MAPT antikoerper

Molekulargewicht: 80 kDa

Gen-ID: 4137

UniProt: P10636