JAG1 Antikörper (Internal Region)

Produktnummer ABIN6285442

Produktdetails anti-JAG1 Antikörper

Target: JAG1 (Jagged 1 (JAG1))

Bindungsspezifität: AA 981-1030, Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Jagged1 is a protein encoded by the JAG1 gene which is approximately 133,7 kDa. Jagged1 is localised to the plasma membrane. It is involved in signalling by Notch1, Notch2 activation and transmission of signal to the nucleus and the HIV life cycle. It is a ligand for multiple Notch receptors and may also be involved in cell-fate decisions during hematopoiesis and in the early and late stages of mammalian cardiovascular development. Jagged1 is widely expressed in adult and foetal tissues. Mutations in the JAG1 gene may result in Alagille syndrome. STJ96766 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Jagged1 protein.

Spezifität: Jagged1 Polyclonal Antibody detects endogenous levels of Jagged1 protein.

Produktmerkmale: Rabbit polyclonal to Jagged1.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Jagged1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000

Kommentare:

Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu JAG1

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: Jagged1 (JAG1 Produkte)

Synonyme: AGS antikoerper, AHD antikoerper, AWS antikoerper, CD339 antikoerper, HJ1 antikoerper, JAGL1 antikoerper, ABE2 antikoerper, Gsfabe2 antikoerper, Htu antikoerper, Ozz antikoerper, Ser-1 antikoerper, JAG1 antikoerper, jag3 antikoerper, cb243 antikoerper, jag1 antikoerper, sb:cb243 antikoerper, serrateC antikoerper, jagged1 antikoerper, serrate antikoerper, serrate-1 antikoerper, x-serrate-1 antikoerper, jagged 1 antikoerper, jagged 1b antikoerper, jagged 1a antikoerper, jagged 1 L homeolog antikoerper, JAG1 antikoerper, Jag1 antikoerper, jag1 antikoerper, jag1b antikoerper, jag1a antikoerper, jag1.L antikoerper

Molekulargewicht: 140 kDa

Gen-ID: 182

UniProt: P78504

Pathways: Notch Signalweg, Stem Cell Maintenance