Kv2.1/KCNB1 Antikörper (AA 510-590)

Produktnummer ABIN6284347

Produktdetails anti-Kv2.1/KCNB1 Antikörper

Target: Kv2.1/KCNB1 (KCNB1) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1))

Bindungsspezifität: AA 510-590

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kv2.1/KCNB1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Kv2.1 is a protein encoded by the KCNB1 gene which is approximately 95,8 kDa. Kv2.1 is localised to the cell membrane. It is involved in integration of energy metabolism, potassium channels and aquaporin-mediated transport. It contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and also plays a role in homeostatic attenuation of electrical excitability throughout the brain. Kv2.1 is expressed in the brain, heart, lung, liver, colon, kidney and adrenal gland. Mutations in the KCNB1 gene may result in epileptic encephalopathy. STJ93873 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Kv2.1 protein.

Spezifität: Kv2.1 Polyclonal Antibody detects endogenous levels of Kv2.1 protein.

Produktmerkmale: Rabbit polyclonal to Kv2.1.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Kv2.1 around the non-phosphorylation site of S567.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000

Kommentare:

Expressed in neocortical pyramidal cells . Expressed in pancreatic beta cells (at protein level) . Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland . Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu Kv2.1/KCNB1

Target: Kv2.1/KCNB1 (KCNB1) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1))

Andere Bezeichnung: Kv2.1 (KCNB1 Produkte)

Synonyme: KCNB1 antikoerper, Kcnb1 antikoerper, Kcr1-1 antikoerper, Kv2.1 antikoerper, Shab antikoerper, DRK1PC antikoerper, DRK1 antikoerper, KV2.1 antikoerper, h-DRK1 antikoerper, potassium voltage-gated channel subfamily B member 1 antikoerper, potassium voltage-gated channel, Shab-related subfamily, member 1 antikoerper, potassium channel, voltage gated Shab related subfamily B, member 1 antikoerper, potassium voltage gated channel, Shab-related subfamily, member 1 antikoerper, KCNB1 antikoerper, kcnb1 antikoerper, LOC100541632 antikoerper, Kcnb1 antikoerper

Molekulargewicht: 90 kDa

Gen-ID: 3745

UniProt: Q14721

Pathways: Synaptic Membrane