CaMKIIbeta/gamma/delta Antikörper (pThr287)
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- Target Alle CaMKIIbeta/gamma/delta Produkte
- CaMKIIbeta/gamma/delta
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Bindungsspezifität
- AA 230-310, pThr287
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CaMKIIbeta/gamma/delta Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Verwendungszweck
- CaMKIIβ/γ/δ is a protein encoded by the CAMK2B gene which is approximately 72,6 kDa. CaMKIIβ/γ/δ is localised to the cytoplasm. It is involved in RET signalling, post NMDA receptor activation events and cardiac conduction. It is a calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation. It plays a role in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. CaMKIIβ/γ/δ is widely expressed in human tissue including the adult and foetal brain. The CAMK2B gene is associated with Phencyclidine abuse. STJ90941 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous CaMKIIβ/γ/δ protein which only binds about T287 when T287 is phosphorylated.
- Spezifität
- Phospho-CaMKIIβ/γ/δ (T287) Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ/δ protein only when phosphorylated at T287.
- Produktmerkmale
- Rabbit polyclonal to Phospho-CaMKIIβ/γ/δ (T287).
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human CaMKIIbeta/gamma/delta around the phosphorylation site of T287.
- Isotyp
- IgG
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- Applikationshinweise
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WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000 - Kommentare
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Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- CaMKIIbeta/gamma/delta
- Abstract
- CaMKIIbeta/gamma/delta Produkte
- Molekulargewicht
- 50/65 kDa
- Gen-ID
- 816
- UniProt
- Q13554
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