OTUB1 Antikörper (Internal Region)

Produktnummer ABIN6282055

Produktdetails anti-OTUB1 Antikörper

Target: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Bindungsspezifität: AA 20-100, Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Otubain-1 is a protein encoded by the OTUB1 gene which is approximately 31,3 kDa. Otubain-1 is localised to the cytoplasm and is involved in deubiquitination, metabolism of proteins, DNA damage and ovarian tumor domain proteases. Otubain-1 is a member of the ovarian tumor superfamily. It interacts with another ubiquitin protease and an E3 ubiquitin ligase whicj inhibits cytokine gene transcription in the immune system. It also plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites. Isoform 1 of otubain-1 is ubiquitously expressed while isoform 2 is expressed only in lymphoid tissues as well as peripheral blood mononuclear cells. Mutations in the OTUB1 gene may result in retinitis pigmentosa. STJ97632 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of otubain-1 protein.

Spezifität: Otubain-1 Polyclonal Antibody detects endogenous levels of Otubain-1 protein.

Produktmerkmale: Rabbit polyclonal to Otubain-1.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Otubain-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
ELISA 1:10000

Kommentare:

Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu OTUB1

Target: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Andere Bezeichnung: Otubain-1 (OTUB1 Produkte)

Synonyme: OTB1 antikoerper, OTU1 antikoerper, AI850305 antikoerper, fa19h07 antikoerper, otub1 antikoerper, wu:fa19h07 antikoerper, zgc:92839 antikoerper, MGC131231 antikoerper, fb17f04 antikoerper, otub1l antikoerper, wu:fb17f04 antikoerper, zgc:92685 antikoerper, OTU deubiquitinase, ubiquitin aldehyde binding 1 antikoerper, OTU domain, ubiquitin aldehyde binding 1 antikoerper, OTU deubiquitinase, ubiquitin aldehyde binding 1b antikoerper, OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog antikoerper, similar to HSPC263 antikoerper, OTU deubiquitinase, ubiquitin aldehyde binding 1a antikoerper, OTUB1 antikoerper, Otub1 antikoerper, otub1b antikoerper, otub1.L antikoerper, otub1 antikoerper, RGD1565010 antikoerper, otub1a antikoerper

Gen-ID: 55611

UniProt: Q96FW1