MARK1/2/3/4 Antikörper (AA 150-230)
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- Target Alle MARK1/2/3/4 Produkte
- MARK1/2/3/4 (MAP/microtubule Affinity-Regulating Kinase 1/2/3/4 (MARK1/2/3/4))
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Bindungsspezifität
- AA 150-230
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Reaktivität
- Human, Maus, Ratte, Affe
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MARK1/2/3/4 Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Verwendungszweck
- MARK1/2/3/4 is a protein encoded by the MARK1 gene which is approximately 89 kDa. MARK1/2/3/4 is localised to the cell membrane and cytoplasm. It is involved in cytoplasm signalling and glucose/energy metabolism. It plays a role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1/2/3/4 is highly expressed in the heart, skeletal muscle, brain and foetal kidney. Mutations in the MARK1 gene may result in Alzheimer disease. STJ94015 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MARK1/2/3/4 protein.
- Spezifität
- MARK1/2/3/4 Polyclonal Antibody detects endogenous levels of MARK1/2/3/4 protein.
- Produktmerkmale
- Rabbit polyclonal to MARK1/2/3/4.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human MARK1/2/3/4 around the non-phosphorylation site of T215.
- Isotyp
- IgG
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- Applikationshinweise
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WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000 - Kommentare
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Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- MARK1/2/3/4 (MAP/microtubule Affinity-Regulating Kinase 1/2/3/4 (MARK1/2/3/4))
- Andere Bezeichnung
- MARK1/2/3/4 (MARK1/2/3/4 Produkte)
- Molekulargewicht
- 89 kDa
- Gen-ID
- 4139
- UniProt
- Q9P0L2
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