THRAP3 Antikörper (N-Term)

Produktnummer ABIN6265560

Produktdetails anti-THRAP3 Antikörper

Target: THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRAP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: THRAP3 Antibody detects endogenous levels of total THRAP3.

Homologie: Bovine,Sheep,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human THRAP3, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu THRAP3

Target: THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))

Andere Bezeichnung: THRAP3 (THRAP3 Produkte)

Synonyme: TRAP150 antikoerper, 9330151F09Rik antikoerper, B230333E16Rik antikoerper, Trap150 antikoerper, trap150 antikoerper, Thrap3 antikoerper, MGC132228 antikoerper, zgc:85716 antikoerper, thyroid hormone receptor associated protein 3 antikoerper, DNA cross-link repair 1A protein antikoerper, thyroid hormone receptor associated protein 3 S homeolog antikoerper, thyroid hormone receptor-associated protein 3 antikoerper, thyroid hormone receptor associated protein 3b antikoerper, THRAP3 antikoerper, CpipJ_CPIJ018886 antikoerper, CpipJ_CPIJ019503 antikoerper, Thrap3 antikoerper, thrap3 antikoerper, thrap3.S antikoerper, thrap3b antikoerper

Hintergrund:

Description: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition, the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex, however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene: THRAP3

Molekulargewicht: 109kDa

Gen-ID: 9967

UniProt: Q9Y2W1

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway