SMARCA5 Antikörper (C-Term)

Produktnummer ABIN6265180

Produktdetails anti-SMARCA5 Antikörper

Target: SMARCA5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5 (SMARCA5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCA5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: SMARCA5 Antibody detects endogenous levels of total SMARCA5.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SMARCA5, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu SMARCA5

Target: SMARCA5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5 (SMARCA5))

Andere Bezeichnung: SMARCA5 (SMARCA5 Produkte)

Synonyme: fb26d12 antikoerper, fb49g04 antikoerper, chunp6878 antikoerper, im:7146484 antikoerper, wu:fb26d12 antikoerper, wu:fb49g04 antikoerper, zgc:158434 antikoerper, smarca5 antikoerper, iswi antikoerper, SMARCA5 antikoerper, hiswi antikoerper, snf2h antikoerper, hsnf2h antikoerper, wcrf135 antikoerper, MGC79455 antikoerper, ISWI antikoerper, SNF2H antikoerper, WCRF135 antikoerper, hISWI antikoerper, hSNF2H antikoerper, 4933427E24Rik antikoerper, D030040M08Rik antikoerper, D330027N15Rik antikoerper, MommeD4 antikoerper, Snf2h antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog antikoerper, smarca5 antikoerper, smarca5.S antikoerper, SMARCA5 antikoerper, Smarca5 antikoerper

Hintergrund:

Description: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin, this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.

Gene: SMARCA5

Molekulargewicht: 122kDa

Gen-ID: 8467

UniProt: O60264

Pathways: Chromatin Binding