Mahogunin RING Finger Protein 1 Antikörper (Internal Region)

Produktnummer ABIN6264784

Produktdetails anti-Mahogunin RING Finger Protein 1 Antikörper

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Mahogunin RING Finger Protein 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: RNF156 Antibody detects endogenous levels of total RNF156.

Homologie: Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RNF156, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Mahogunin RING Finger Protein 1

Target: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Andere Bezeichnung: MGRN1 (MGRN1 Produkte)

Synonyme: RNF156 antikoerper, 2610042J20Rik antikoerper, mKIAA0544 antikoerper, md antikoerper, nc antikoerper, RGD1311862 antikoerper, mgrn1 antikoerper, wu:fi38c03 antikoerper, zgc:55978 antikoerper, mahogunin ring finger 1 antikoerper, mahogunin, ring finger 1 antikoerper, mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog antikoerper, mahogunin ring finger 1, E3 ubiquitin protein ligase antikoerper, mahogunin, ring finger 1a antikoerper, MGRN1 antikoerper, Mgrn1 antikoerper, mgrn1.S antikoerper, mgrn1 antikoerper, mgrn1a antikoerper

Hintergrund:

Description: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).

Gene: MGRN1

Molekulargewicht: 66-72 kDa,55 kDa

Gen-ID: 23295

UniProt: O60291

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling