RBBP6 Antikörper (Internal Region)

Produktnummer ABIN6279764

Produktdetails anti-RBBP6 Antikörper

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBBP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: RBBP6 Antibody detects endogenous levels of total RBBP6.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RBBP6, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RBBP6

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Andere Bezeichnung: RBBP6 (RBBP6 Produkte)

Synonyme: MY038 antikoerper, P2P-R antikoerper, PACT antikoerper, RBQ-1 antikoerper, SNAMA antikoerper, 4933422O15Rik antikoerper, AI316869 antikoerper, BB233631 antikoerper, C030034J04Rik antikoerper, C77662 antikoerper, rbbp6 antikoerper, MGC75882 antikoerper, RBBP6 antikoerper, im:7158869 antikoerper, rbbp6l antikoerper, RB binding protein 6, ubiquitin ligase antikoerper, retinoblastoma binding protein 6, ubiquitin ligase antikoerper, retinoblastoma binding protein 6 antikoerper, RBBP6 antikoerper, Rbbp6 antikoerper, rbbp6 antikoerper

Hintergrund:

Description: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

Gene: RBBP6

Molekulargewicht: 202 kDa

Gen-ID: 5930

UniProt: Q7Z6E9

Pathways: Regulatorische RNA Pathways