PTPRN2 Antikörper (Internal Region)

Produktnummer ABIN6264511

Produktdetails anti-PTPRN2 Antikörper

Target: PTPRN2 (Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPRN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: PTP IA-2beta Antibody detects endogenous levels of total PTP IA-2beta.

Homologie: Pig,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PTP IA-2beta, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PTPRN2

Target: PTPRN2 (Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2))

Andere Bezeichnung: PTPRN2 (PTPRN2 Produkte)

Synonyme: IA-2beta antikoerper, IAR antikoerper, ICAAR antikoerper, PTPRP antikoerper, R-PTP-N2 antikoerper, 4930425H11Rik antikoerper, IA2beta antikoerper, PTP-NP antikoerper, Phol antikoerper, mKIAA0387 antikoerper, phogrin antikoerper, protein tyrosine phosphatase, receptor type N2 antikoerper, protein tyrosine phosphatase, receptor type, N polypeptide 2 antikoerper, PTPRN2 antikoerper, Ptprn2 antikoerper

Hintergrund:

Description: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity, the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis, upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).

Gene: PTPRN2

Molekulargewicht: 111kDa

Gen-ID: 5799

UniProt: Q92932