PITX3 Antikörper

Produktnummer ABIN6264234

Produktdetails anti-PITX3 Antikörper

Target: PITX3 (Pituitary Homeobox 3 (PITX3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PITX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: PITX3 Antibody detects endogenous levels of total PITX3

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PITX3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000 IHC 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu PITX3

Target: PITX3 (Pituitary Homeobox 3 (PITX3))

Andere Bezeichnung: PITX3 (PITX3 Produkte)

Synonyme: CTPP4 antikoerper, CTRCT11 antikoerper, PTX3 antikoerper, pitx3 antikoerper, Ptx3 antikoerper, ak antikoerper, zgc:109716 antikoerper, pitx3-A antikoerper, xPitx3 antikoerper, paired like homeodomain 3 antikoerper, paired-like homeodomain 3 antikoerper, paired like homeodomain 3 L homeolog antikoerper, paired-like homeodomain transcription factor 3 antikoerper, paired-like homeodomain transcription factor Pitx3 antikoerper, PITX3 antikoerper, Pitx3 antikoerper, pitx3.L antikoerper, pitx3 antikoerper

Hintergrund:

Description: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

Gene: PITX3

Molekulargewicht: 32 kDa

Gen-ID: 5309

UniProt: O75364