PHF19 Antikörper (Internal Region)

Produktnummer ABIN6264174

Produktdetails anti-PHF19 Antikörper

Target: PHF19 (PHD Finger Protein 19 (PHF19))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHF19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: PHF19 Antibody detects endogenous levels of total PHF19.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PHF19, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PHF19

Target: PHF19 (PHD Finger Protein 19 (PHF19))

Andere Bezeichnung: PHF19 (PHF19 Produkte)

Synonyme: si:dkeyp-51b7.1 antikoerper, pcl3 antikoerper, MGC147603 antikoerper, MTF2L1 antikoerper, PCL3 antikoerper, TDRD19B antikoerper, 3110009G19Rik antikoerper, 3321402G02Rik antikoerper, PHD finger protein 19 antikoerper, Phf19 antikoerper, PHF19 antikoerper, phf19 antikoerper

Hintergrund:

Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.

Gene: PHF19

Molekulargewicht: 66 kDa

Gen-ID: 26147

UniProt: Q5T6S3

Pathways: Stem Cell Maintenance