MITF Antikörper (Internal Region)

Produktnummer ABIN6263260

Produktdetails anti-MITF Antikörper

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MITF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Spezifität: MITF Antibody detects endogenous levels of total MITF.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MITF, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Andere Bezeichnung: MITF (MITF Produkte)

Synonyme: MITF antikoerper, ws2a antikoerper, mitfa antikoerper, MITF-A antikoerper, LOC100313655 antikoerper, mitfb antikoerper, CMM8 antikoerper, MI antikoerper, WS2 antikoerper, WS2A antikoerper, bHLHe32 antikoerper, BCC2 antikoerper, Bhlhe32 antikoerper, Gsfbcc2 antikoerper, Vitiligo antikoerper, Wh antikoerper, bw antikoerper, mi antikoerper, vit antikoerper, MITF-H antikoerper, MITF-M antikoerper, CMI9 antikoerper, melanogenesis associated transcription factor antikoerper, microphthalmia-associated transcription factor antikoerper, microphthalmia-associated transcription factor S homeolog antikoerper, Microphthalmia antikoerper, MITF antikoerper, mitf antikoerper, LOC100313655 antikoerper, mitf.S antikoerper, LOC100534525 antikoerper, MICROP antikoerper, Mitf antikoerper

Hintergrund:

Description: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Gene: MITF

Molekulargewicht: 59kDa

Gen-ID: 4286

UniProt: O75030

Pathways: Chromatin Binding