LGALS8 Antikörper (Internal Region)

Produktnummer ABIN6262956

Produktdetails anti-LGALS8 Antikörper

Target: LGALS8 (Lectin, Galactoside-Binding, Soluble, 8 (LGALS8))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LGALS8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Galectin 8 Antibody detects endogenous levels of total Galectin 8.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Galectin 8, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu LGALS8

Target: LGALS8 (Lectin, Galactoside-Binding, Soluble, 8 (LGALS8))

Andere Bezeichnung: LGALS8 (LGALS8 Produkte)

Synonyme: LGALS8 antikoerper, 1200015E08Rik antikoerper, AI326142 antikoerper, D13Ertd524e antikoerper, Lgals-8 antikoerper, galectin-8 antikoerper, Gal-8 antikoerper, PCTA-1 antikoerper, PCTA1 antikoerper, Po66-CBP antikoerper, xgalectin-VIIIa antikoerper, galectin 8 antikoerper, lectin, galactose binding, soluble 8 antikoerper, lectin, galactoside binding soluble 8 S homeolog antikoerper, LGALS8 antikoerper, Lgals8 antikoerper, lgals8.S antikoerper

Hintergrund:

Description: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane, these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).

Gene: LGALS8

Molekulargewicht: 40 kDa

Gen-ID: 3964

UniProt: O00214