KCNQ1 Antikörper (C-Term)

Produktnummer ABIN6262757

Produktdetails anti-KCNQ1 Antikörper

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNQ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: KCNQ1 Antibody detects endogenous levels of total KCNQ1.

Homologie: Horse,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KCNQ1, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu KCNQ1

Target: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Andere Bezeichnung: KCNQ1 (KCNQ1 Produkte)

Synonyme: ATFB1 antikoerper, ATFB3 antikoerper, JLNS1 antikoerper, KCNA8 antikoerper, KCNA9 antikoerper, KVLQT1 antikoerper, Kv1.9 antikoerper, Kv7.1 antikoerper, LQT antikoerper, LQT1 antikoerper, RWS antikoerper, SQT2 antikoerper, WRS antikoerper, CG12215 antikoerper, CG12915 antikoerper, CG33135 antikoerper, DKCNQ antikoerper, Dmel\\CG33135 antikoerper, dKCNQ antikoerper, kcnq1 antikoerper, KCNQ1 antikoerper, kqt-3 antikoerper, kv7.1 antikoerper, Kvlqt1 antikoerper, KvLQT-1 antikoerper, kcnq1-A antikoerper, xkvlqt1 antikoerper, zgc:158384 antikoerper, AW559127 antikoerper, Kcna9 antikoerper, KvLQT1 antikoerper, potassium voltage-gated channel subfamily Q member 1 antikoerper, KCNQ potassium channel antikoerper, potassium voltage-gated channel, KQT-like subfamily, member 1 antikoerper, potassium channel, voltage gated KQT-like subfamily Q, member 1 antikoerper, voltage gated potassium channel subunit antikoerper, potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog antikoerper, potassium voltage-gated channel, subfamily Q, member 1 antikoerper, KCNQ1 antikoerper, KCNQ antikoerper, kcnq1 antikoerper, Kcnq1 antikoerper, kcnq1.L antikoerper

Hintergrund:

Description: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5, has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568).

Gene: KCNQ1

Molekulargewicht: 61kDa

Gen-ID: 3784

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound