HSPA2 Antikörper

Produktnummer ABIN6262410

Produktdetails anti-HSPA2 Antikörper

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: HSPA2 Antibody detects endogenous levels of total HSPA2

Kreuzreaktivität: Human

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HSPA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu HSPA2

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Andere Bezeichnung: HSPA2 (HSPA2 Produkte)

Synonyme: HSP70-2 antikoerper, HSP70-3 antikoerper, HSPA2 antikoerper, DKFZp468B217 antikoerper, 70kDa antikoerper, HSP70.2 antikoerper, HSP70A2 antikoerper, Hsp70-2 antikoerper, Hspt70 antikoerper, Hst70 antikoerper, HSPA3 antikoerper, heat shock protein family A (Hsp70) member 2 antikoerper, heat shock protein Hsp20 antikoerper, heat shock 70kDa protein 2 antikoerper, heat shock protein 2 antikoerper, heat shock protein family A member 2 antikoerper, HSPA2 antikoerper, hspA2 antikoerper, Hspa2 antikoerper

Hintergrund:

Description: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Gene: HSPA2

Molekulargewicht: 70 kDa

Gen-ID: 3306

UniProt: P54652