HOMER1 Antikörper (Internal Region)

Produktnummer ABIN6262337

Produktdetails anti-HOMER1 Antikörper

Target: HOMER1 (Homer Homolog 1 (HOMER1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HOMER1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: HOMER1 Antibody detects endogenous levels of total HOMER1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HOMER1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu HOMER1

Target: HOMER1 (Homer Homolog 1 (HOMER1))

Andere Bezeichnung: HOMER1 (HOMER1 Produkte)

Synonyme: HOMER antikoerper, HOMER1A antikoerper, HOMER1B antikoerper, HOMER1C antikoerper, SYN47 antikoerper, Ves-1 antikoerper, HOMER1 antikoerper, PSD-Zip45 antikoerper, homer1 antikoerper, zgc:100854 antikoerper, zgc:92844 antikoerper, HOMER1F antikoerper, Vesl-1 antikoerper, homer antikoerper, xhomer1 antikoerper, BEST:LD03829 antikoerper, CG11324 antikoerper, Dhom antikoerper, Dhomer antikoerper, Dm Homer antikoerper, Dmel\CG11324 antikoerper, Dvh antikoerper, Hom antikoerper, Homer antikoerper, LD03829 antikoerper, dhom antikoerper, homer scaffolding protein 1 antikoerper, homer scaffolding protein 1b antikoerper, homer scaffolding protein 1 L homeolog antikoerper, CG11324 gene product from transcript CG11324-RD antikoerper, HOMER1 antikoerper, Homer1 antikoerper, homer1b antikoerper, homer1.L antikoerper, homer antikoerper

Hintergrund:

Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

Gene: HOMER1

Molekulargewicht: 46-48 kDa

Gen-ID: 9456

UniProt: Q86YM7

Pathways: Skeletal Muscle Fiber Development