GDF6 Antikörper (C-Term)

Produktnummer ABIN6261929

Produktdetails anti-GDF6 Antikörper

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GDF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: GDF6 Antibody detects endogenous levels of total GDF6.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GDF6, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu GDF6

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Andere Bezeichnung: GDF6 (GDF6 Produkte)

Synonyme: BMP13 antikoerper, CDMP2 antikoerper, KFM antikoerper, KFS antikoerper, KFS1 antikoerper, KFSL antikoerper, LCA17 antikoerper, MCOP4 antikoerper, MCOPCB6 antikoerper, SCDO4 antikoerper, SGM1 antikoerper, GDF16 antikoerper, gdf16 antikoerper, CDMP-2 antikoerper, gdf6 antikoerper, rdr antikoerper, sb:cb278 antikoerper, bmp13 antikoerper, cdmp2 antikoerper, gdf-6 antikoerper, kfs antikoerper, kfsl antikoerper, sgm1 antikoerper, growth differentiation factor 6 antikoerper, growth differentiation factor 6a antikoerper, growth differentiation factor 6 S homeolog antikoerper, GDF6 antikoerper, Gdf6 antikoerper, gdf6 antikoerper, gdf6a antikoerper, gdf6.S antikoerper

Hintergrund:

Description: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).

Gene: GDF6

Molekulargewicht: 51 kDa

Gen-ID: 392255

UniProt: Q6KF10