SHFM1 Antikörper
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- Target Alle SHFM1 Antikörper anzeigen
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SHFM1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Western Blotting (WB)
- Spezifität
- DSS1 antibody detects endogenous levels of DSS1.
- Kreuzreaktivität
- Human, Ratte (Rattus)
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human DSS1.
- Isotyp
- IgG
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
- Haltbarkeit
- 12 months
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- Target
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
- Andere Bezeichnung
- DSS1 (SHFM1 Produkte)
- Synonyme
- DSS1 antikoerper, ECD antikoerper, SEM1 antikoerper, SHFD1 antikoerper, SHSF1 antikoerper, Shfdg1 antikoerper, Shfg antikoerper, Dss1 antikoerper, SHFM1 antikoerper, dss1 antikoerper, ecd antikoerper, sem1 antikoerper, shfd1 antikoerper, shfdg1 antikoerper, shfm1 antikoerper, shfm1.S antikoerper, shsf1 antikoerper, wu:fb55c02 antikoerper, zgc:56203 antikoerper, zgc:85901 antikoerper, SEM1, 26S proteasome complex subunit antikoerper, SEM1, 26S proteasome complex subunit S homeolog antikoerper, SEM1 antikoerper, Sem1 antikoerper, sem1.S antikoerper, sem1 antikoerper
- Hintergrund
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Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
Gene: SEM1
- Molekulargewicht
- 8-10 kDa
- Gen-ID
- 7979
- UniProt
- P60896
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