DNAJB2 Antikörper (Internal Region)

Produktnummer ABIN6261330

Produktdetails anti-DNAJB2 Antikörper

Target: DNAJB2 (DnaJ (Hsp40) Homolog, Subfamily B, Member 2 (DNAJB2))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAJB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: DNAJB2 Antibody detects endogenous levels of total DNAJB2.

Homologie: Pig,Bovine,Horse,Sheep,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DNAJB2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu DNAJB2

Target: DNAJB2 (DnaJ (Hsp40) Homolog, Subfamily B, Member 2 (DNAJB2))

Andere Bezeichnung: DNAJB2 (DNAJB2 Produkte)

Synonyme: MGC78895 antikoerper, DSMA5 antikoerper, HSJ-1 antikoerper, HSJ1 antikoerper, HSPF3 antikoerper, 2700059H22Rik antikoerper, Dnajb10 antikoerper, Hsj1 antikoerper, mDj8 antikoerper, DnaJ heat shock protein family (Hsp40) member B2 L homeolog antikoerper, DnaJ heat shock protein family (Hsp40) member B2 antikoerper, dnajb2.L antikoerper, DNAJB2 antikoerper, dnajb2 antikoerper, Dnajb2 antikoerper

Hintergrund:

Description: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).

Gene: DNAJB2

Molekulargewicht: 36 kDa

Gen-ID: 3300

UniProt: P25686