DMAP1 Antikörper (Internal Region)

Produktnummer ABIN6261316

Produktdetails anti-DMAP1 Antikörper

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: DMAP1 Antibody detects endogenous levels of total DMAP1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DMAP1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu DMAP1

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Andere Bezeichnung: DMAP1 (DMAP1 Produkte)

Synonyme: Afu4g07380 antikoerper, T8I13.5 antikoerper, DNMAP1 antikoerper, DNMTAP1 antikoerper, EAF2 antikoerper, MEAF2 antikoerper, SWC4 antikoerper, zgc:55593 antikoerper, dnmap1 antikoerper, dnmtap1 antikoerper, eaf2 antikoerper, meaf2 antikoerper, swc4 antikoerper, 1500016M21Rik antikoerper, Dmtap1 antikoerper, mKIAA1425 antikoerper, DNA methyltransferase 1-associated protein DMAP1 antikoerper, DNA methyltransferase 1-associated protein 1 antikoerper, DNA methyltransferase 1 associated protein 1 antikoerper, myb-like transcription factor family protein antikoerper, DNA methyltransferase 1 associated protein 1 L homeolog antikoerper, AFUA_4G07380 antikoerper, NFIA_108840 antikoerper, ACLA_046700 antikoerper, CpipJ_CPIJ017959 antikoerper, Bm1_47540 antikoerper, PMAA_026820 antikoerper, AFLA_112450 antikoerper, TSTA_072020 antikoerper, BDBG_02603 antikoerper, AT2G47210 antikoerper, CpipJ_CPIJ007438 antikoerper, DMAP1 antikoerper, dmap1 antikoerper, dmap1.L antikoerper, Dmap1 antikoerper

Hintergrund:

Description: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Gene: DMAP1

Molekulargewicht: 53 kDa

Gen-ID: 55929

UniProt: Q9NPF5