DDX21 Antikörper (Internal Region)

Produktnummer ABIN6261252

Produktdetails anti-DDX21 Antikörper

Target: DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDX21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: DDX21 Antibody detects endogenous levels of total DDX21.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DDX21, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu DDX21

Target: DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

Andere Bezeichnung: DDX21 (DDX21 Produkte)

Synonyme: MGC130693 antikoerper, DDX21 antikoerper, cb960 antikoerper, wu:fi30c07 antikoerper, wu:fi34d08 antikoerper, GUA antikoerper, GURDB antikoerper, RH-II/GU antikoerper, RH-II/GuA antikoerper, Ddx21a antikoerper, AI255159 antikoerper, AL022742 antikoerper, D10Ertd645e antikoerper, D10Wsu42e antikoerper, DEAD-box helicase 21 L homeolog antikoerper, DExD-box helicase 21 antikoerper, DEAD-box helicase 21 antikoerper, DEAD (Asp-Glu-Ala-Asp) box helicase 21 antikoerper, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 antikoerper, ddx21.L antikoerper, DDX21 antikoerper, ddx21 antikoerper, Ddx21 antikoerper

Hintergrund:

Description: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233).

Gene: DDX21

Molekulargewicht: 87 kDa

Gen-ID: 9188

UniProt: Q9NR30

Pathways: SARS-CoV-2 Protein Interaktom