CPSF6 Antikörper (Internal Region)

Produktnummer ABIN6261008

Produktdetails anti-CPSF6 Antikörper

Target: CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPSF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: CPSF6 Antibody detects endogenous levels of total CPSF6.

Homologie: Bovine,Horse,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CPSF6, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CPSF6

Target: CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))

Andere Bezeichnung: CPSF6 (CPSF6 Produkte)

Synonyme: CPSF6 antikoerper, wu:fa22f12 antikoerper, zgc:85819 antikoerper, 4733401N12Rik antikoerper, AI256641 antikoerper, CFIM antikoerper, CFIM68 antikoerper, HPBRII-4 antikoerper, HPBRII-7 antikoerper, cleavage and polyadenylation specific factor 6 antikoerper, cleavage and polyadenylation specific factor 6 S homeolog antikoerper, CPSF6 antikoerper, cpsf6.S antikoerper, cpsf6 antikoerper, Cpsf6 antikoerper

Hintergrund:

Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).

Gene: CPSF6

Molekulargewicht: 59 kDa

Gen-ID: 11052

UniProt: Q16630