CPSF6 Antikörper (Internal Region)
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- Target Alle CPSF6 Antikörper anzeigen
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CPSF6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- CPSF6 Antibody detects endogenous levels of total CPSF6.
- Homologie
- Bovine,Horse,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CPSF6, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product CPSF6 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
- Andere Bezeichnung
- CPSF6 (CPSF6 Produkte)
- Synonyme
- CPSF6 antikoerper, wu:fa22f12 antikoerper, zgc:85819 antikoerper, 4733401N12Rik antikoerper, AI256641 antikoerper, CFIM antikoerper, CFIM68 antikoerper, HPBRII-4 antikoerper, HPBRII-7 antikoerper, cleavage and polyadenylation specific factor 6 antikoerper, cleavage and polyadenylation specific factor 6 S homeolog antikoerper, CPSF6 antikoerper, cpsf6.S antikoerper, cpsf6 antikoerper, Cpsf6 antikoerper
- Hintergrund
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Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).
Gene: CPSF6
- Molekulargewicht
- 59 kDa
- Gen-ID
- 11052
- UniProt
- Q16630
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