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CHD8 Antikörper (C-Term)

CHD8 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6260798
  • Target Alle CHD8 Antikörper anzeigen
    CHD8 (Chromodomain Helicase DNA Binding Protein 8 (CHD8))
    Bindungsspezifität
    • 3
    • 2
    • 2
    • 1
    C-Term
    Reaktivität
    • 15
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 13
    • 2
    Kaninchen
    Klonalität
    • 14
    • 1
    Polyklonal
    Konjugat
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CHD8 Antikörper ist unkonjugiert
    Applikation
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Spezifität
    CHD8 Antibody detects endogenous levels of total CHD8.
    Homologie
    Bovine,Horse,Sheep,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CHD8, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CHD8 (Chromodomain Helicase DNA Binding Protein 8 (CHD8))
    Andere Bezeichnung
    CHD8 (CHD8 Produkte)
    Synonyme
    CHD8 antikoerper, Chd8 antikoerper, CHD-8 antikoerper, AUTS18 antikoerper, HELSNF1 antikoerper, 5830451P18Rik antikoerper, AU015341 antikoerper, Duplin antikoerper, mKIAA1564 antikoerper, fi45h08 antikoerper, si:ch211-10e2.6 antikoerper, wu:fi45h08 antikoerper, chromodomain helicase DNA binding protein 8 antikoerper, CHD8 antikoerper, chd8 antikoerper, Chd8 antikoerper
    Hintergrund

    Description: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

    Gene: CHD8

    Molekulargewicht
    290kDa
    Gen-ID
    57680
    UniProt
    Q9HCK8
    Pathways
    Chromatin Binding
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