BVES Antikörper (Internal Region)

Produktnummer ABIN6260332

Produktdetails anti-BVES Antikörper

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BVES Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: BVES Antibody detects endogenous levels of total BVES.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BVES, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BVES

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Andere Bezeichnung: BVES (BVES Produkte)

Synonyme: HBVES antikoerper, POP1 antikoerper, POPDC1 antikoerper, Pop1 antikoerper, Popdc1 antikoerper, mBVES antikoerper, Popeye-1 antikoerper, Xbves antikoerper, Xbves-A antikoerper, Xpop-1 antikoerper, Xpop-1-A antikoerper, pop-1 antikoerper, pop1 antikoerper, pop1-A antikoerper, popdc1 antikoerper, popdc1-A antikoerper, zgc:86887 antikoerper, BVES antikoerper, Xpop-1-B antikoerper, bves antikoerper, pop1-B antikoerper, popdc1-B antikoerper, hbves antikoerper, blood vessel epicardial substance antikoerper, blood vessel epicardial substance L homeolog antikoerper, blood vessel epicardial substance S homeolog antikoerper, BVES antikoerper, Bves antikoerper, bves.L antikoerper, bves antikoerper, bves.S antikoerper

Hintergrund:

Description: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca2+-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Gene: BVES

Molekulargewicht: 41kDa

Gen-ID: 11149

UniProt: Q8NE79