ADAM10 Antikörper (Internal Region)

Produktnummer ABIN6259766

Produktdetails anti-ADAM10 Antikörper

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: ADAM10 Antibody detects endogenous levels of total ADAM10.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ADAM10, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Andere Bezeichnung: ADAM10 (ADAM10 Produkte)

Synonyme: ADAM10 antikoerper, Adam10 antikoerper, adam10 antikoerper, wu:fc03d12 antikoerper, ad10 antikoerper, cd156c antikoerper, kuz antikoerper, kuzbanian antikoerper, madm antikoerper, xadam10 antikoerper, ADAM-10 antikoerper, ADAM 10 antikoerper, AD10 antikoerper, CD156c antikoerper, HsT18717 antikoerper, MADM antikoerper, 1700031C13Rik antikoerper, LOC100219653 antikoerper, zgc:64203 antikoerper, ADAM metallopeptidase domain 10 antikoerper, ADAM metallopeptidase domain 10a antikoerper, ADAM metallopeptidase domain 10 S homeolog antikoerper, a disintegrin and metallopeptidase domain 10 antikoerper, ADAM metallopeptidase domain 10b antikoerper, ADAM10 antikoerper, Adam10 antikoerper, adam10a antikoerper, adam10.S antikoerper, adam10b antikoerper

Hintergrund:

Description: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).

Gene: ADAM10

Molekulargewicht: 84 kDa

Gen-ID: 102

UniProt: O14672

Pathways: Notch Signalweg, EGFR Signaling Pathway