ZFP36L2 Antikörper (Internal Region)

Produktnummer ABIN6259621

Produktdetails anti-ZFP36L2 Antikörper

Target: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFP36L2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: TISD Antibody detects endogenous levels of total TISD.

Homologie: Pig,Bovine,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TISD, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ZFP36L2

Target: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Andere Bezeichnung: ZFP36L2 (ZFP36L2 Produkte)

Synonyme: BRF2 antikoerper, ERF-2 antikoerper, ERF2 antikoerper, RNF162C antikoerper, TIS11D antikoerper, Brf2 antikoerper, Tis11d antikoerper, fi22c11 antikoerper, wu:fi22c11 antikoerper, zgc:76924 antikoerper, ZFP36L2 antikoerper, XC3H-3 antikoerper, XC3H-3b antikoerper, c3h-3 antikoerper, zfp36l2 antikoerper, brf2 antikoerper, erf-2 antikoerper, erf2 antikoerper, rnf162c antikoerper, tis11d antikoerper, cb198 antikoerper, cb480 antikoerper, fk89d11 antikoerper, id:ibd1247 antikoerper, sb:cb198 antikoerper, sb:cb480 antikoerper, wu:fb80h11 antikoerper, wu:fb92f07 antikoerper, wu:fk89d11 antikoerper, zfp36l1 antikoerper, zgc:153979 antikoerper, XC3H-2 antikoerper, berg36 antikoerper, brf1 antikoerper, c3h-2 antikoerper, cmg1 antikoerper, erf-1 antikoerper, erf1 antikoerper, rnf162b antikoerper, tis11b antikoerper, zfp36l1-a antikoerper, zfp36l1-b antikoerper, ZFP36 ring finger protein like 2 antikoerper, zinc finger protein 36, C3H type-like 2 antikoerper, ZFP36 ring finger protein-like 2 S homeolog antikoerper, ZFP36 ring finger protein-like 2 L homeolog antikoerper, ZFP36 ring finger protein-like 2 antikoerper, zinc finger protein 36, C3H type-like 1a antikoerper, ZFP36 ring finger protein-like 1 L homeolog antikoerper, ZFP36L2 antikoerper, Zfp36l2 antikoerper, zfp36l2 antikoerper, zfp36l2.S antikoerper, zfp36l2.L antikoerper, zfp36l1a antikoerper, zfp36l1.L antikoerper

Hintergrund:

Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Gene: ZFP36L2

Molekulargewicht: 40 kDa

Gen-ID: 678

UniProt: P47974

Pathways: Stem Cell Maintenance