MUL1 Antikörper (Internal Region)
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- Target Alle MUL1 Antikörper anzeigen
- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MUL1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- MUL1 Antibody detects endogenous levels of total MUL1.
- Homologie
- Pig,Bovine,Horse,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human MUL1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product MUL1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
- Andere Bezeichnung
- MUL1 (MUL1 Produkte)
- Synonyme
- C1orf166 antikoerper, GIDE antikoerper, MAPL antikoerper, MULAN antikoerper, RNF218 antikoerper, RP11-401M16.2 antikoerper, mul1 antikoerper, zgc:92166 antikoerper, 0610009K11Rik antikoerper, AV000801 antikoerper, Gide antikoerper, RGD1309944 antikoerper, im:7146383 antikoerper, zgc:165594 antikoerper, mitochondrial E3 ubiquitin protein ligase 1 antikoerper, mitochondrial E3 ubiquitin protein ligase 1 L homeolog antikoerper, mitochondrial E3 ubiquitin protein ligase 1a antikoerper, mitochondrial ubiquitin ligase activator of NFKB 1 antikoerper, mitochondrial E3 ubiquitin protein ligase 1b antikoerper, MUL1 antikoerper, mul1.L antikoerper, mul1a antikoerper, Mul1 antikoerper, mul1b antikoerper
- Hintergrund
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Description: Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).
Gene: MUL1
- Molekulargewicht
- 38 kDa
- Gen-ID
- 79594
- UniProt
- Q969V5
- Pathways
- Positive Regulation of Endopeptidase Activity
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