EIF3D Antikörper (Internal Region)
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- Target Alle EIF3D Antikörper anzeigen
- EIF3D (Eukaryotic Translation Initiation Factor 3, Subunit D (EIF3D))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EIF3D Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- EIF3D Antibody detects endogenous levels of total EIF3D.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human EIF3D, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product EIF3D Primärantikörper
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- Applikationshinweise
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- EIF3D (Eukaryotic Translation Initiation Factor 3, Subunit D (EIF3D))
- Andere Bezeichnung
- EIF3D (EIF3D Produkte)
- Synonyme
- eif3s7 antikoerper, eIF3d antikoerper, DDBDRAFT_0217568 antikoerper, DDBDRAFT_0219927 antikoerper, DDB_0217568 antikoerper, DDB_0219927 antikoerper, EIF3S7 antikoerper, An15g03780 antikoerper, AO090026000811 antikoerper, eIF3-p66 antikoerper, eIF3-zeta antikoerper, 66/67kDa antikoerper, AA407891 antikoerper, Eif3s7 antikoerper, eIF3p66 antikoerper, wu:fb12a03 antikoerper, zgc:64097 antikoerper, eukaryotic translation initiation factor 3 subunit D antikoerper, eukaryotic translation initiation factor 3 subunit 7 antikoerper, eukaryotic initiation factor antikoerper, eIF-3 zeta antikoerper, eukaryotic translation initiation factor 3, subunit D antikoerper, translation initiation factor eIF-3 subunit 7 antikoerper, eukaryotic translation initiation factor 3 subunit D S homeolog antikoerper, Eukaryotic translation initiation factor 3 subunit D antikoerper, eif3d antikoerper, EIF3D antikoerper, eIF3-S7 antikoerper, ANI_1_540134 antikoerper, AOR_1_1456014 antikoerper, PTRG_07832 antikoerper, VDBG_06053 antikoerper, PGTG_10613 antikoerper, Tsp_00484 antikoerper, Eif3d antikoerper, eif3d.S antikoerper, eif-3.D antikoerper
- Hintergrund
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Description: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
Gene: EIF3D
- Molekulargewicht
- 64 kDa
- Gen-ID
- 8664
- UniProt
- O15371
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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