PHACTR4 Antikörper (Internal Region)

Produktnummer ABIN6257850

Produktdetails anti-PHACTR4 Antikörper

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHACTR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: PHACTR4 Antibody detects endogenous levels of total PHACTR4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PHACTR4, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PHACTR4

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Andere Bezeichnung: PHACTR4 (PHACTR4 Produkte)

Synonyme: 3110001B12Rik antikoerper, AI527228 antikoerper, AW495572 antikoerper, C330013F19Rik antikoerper, N28169 antikoerper, mKIAA4120 antikoerper, phactr4 antikoerper, zgc:63484 antikoerper, zgc:123224 antikoerper, phosphatase and actin regulator 4 antikoerper, phosphatase and actin regulator 4b antikoerper, phosphatase and actin regulator 4 L homeolog antikoerper, phosphatase and actin regulator 4 S homeolog antikoerper, phosphatase and actin regulator 4a antikoerper, Phactr4 antikoerper, phactr4b antikoerper, PHACTR4 antikoerper, phactr4.L antikoerper, phactr4.S antikoerper, Tsp_08786 antikoerper, phactr4 antikoerper, phactr4a antikoerper

Hintergrund:

Description: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

Gene: PHACTR4

Molekulargewicht: 80 kDa

Gen-ID: 65979

UniProt: Q8IZ21

Pathways: Tube Formation