KCNA5 Antikörper (Internal Region)
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- Target Alle KCNA5 Antikörper anzeigen
- KCNA5 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser KCNA5 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- KCNA5 Antibody detects endogenous levels of total KCNA5.
- Homologie
- Pig,Bovine,Horse,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human KCNA5, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
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- Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- KCNA5 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5))
- Andere Bezeichnung
- KCNA5 (KCNA5 Produkte)
- Synonyme
- KCNA5 antikoerper, kcna5 antikoerper, ATFB7 antikoerper, HCK1 antikoerper, HK2 antikoerper, HPCN1 antikoerper, KV1.5 antikoerper, PCN1 antikoerper, Kv1.5 antikoerper, Kv1 antikoerper, potassium voltage-gated channel subfamily A member 5 antikoerper, potassium channel, voltage gated shaker related subfamily A, member 5 antikoerper, potassium voltage-gated channel, shaker-related subfamily, member 5 antikoerper, KCNA5 antikoerper, kcna5 antikoerper, Kcna5 antikoerper
- Hintergrund
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Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well, channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).
Gene: KCNA5
- Molekulargewicht
- 68 kDa
- Gen-ID
- 3741
- UniProt
- P22460
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