CCAR1 Antikörper (Internal Region)

Produktnummer ABIN6257689

Produktdetails anti-CCAR1 Antikörper

Target: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: CCAR1 Antibody detects endogenous levels of total CCAR1.

Homologie: Bovine,Horse,Sheep,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CCAR1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CCAR1

Target: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Andere Bezeichnung: CCAR1 (CCAR1 Produkte)

Synonyme: CCAR1 antikoerper, KIAA1967 antikoerper, ccar1 antikoerper, MGC81663 antikoerper, zehn1480 antikoerper, hm:zehn1480 antikoerper, si:dkey-85g17.2 antikoerper, RP11-437A18.1 antikoerper, CARP-1 antikoerper, 2610511G16Rik antikoerper, 9430036H15Rik antikoerper, Carp1 antikoerper, RGD1560358 antikoerper, cell division cycle and apoptosis regulator 1 antikoerper, cell division cycle and apoptosis regulator 1 L homeolog antikoerper, cell division cycle and apoptosis regulator protein 1 antikoerper, CCAR1 antikoerper, ccar1.L antikoerper, LOC5575286 antikoerper, ccar1 antikoerper, LOC409891 antikoerper, Ccar1 antikoerper

Hintergrund:

Description: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).

Gene: CCAR1

Molekulargewicht: ?132 kDa

Gen-ID: 55749

UniProt: Q8IX12